sinusitis

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	237
interventional	190
Observational	46
Registry	1

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	63
Drug|placebo	34
Device	31
Procedure	20
Drug|Other	6
Other	6
Drug|Procedure	5
Device|Procedure	4
Device|Other	3
Biological|placebo	2
Dietary Supplement|placebo	2
Behavioral	1
Behavioral|Drug	1
Biological	1
Biological|Device	1
Combination Product	1
Combination Product|Other	1
Device|Drug	1
Device|Drug|Procedure	1
Diagnostic Test	1
Diagnostic Test|Other	1
Drug|Other|placebo	1
Drug|Radiation	1
Other|placebo	1
Other|Procedure	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	91
Canada	23
NA	16
Germany	6
France	5
Thailand	4
China	3
Finland	3
Japan	3
Belgium	2
Czechia	2
Israel	2
Italy	2
Norway	2
Turkey	2
Australia|New Zealand	1
Belgium|Germany	1
Belgium|Israel	1
Bulgaria|Canada|Czechia|Estonia|Germany|Netherlands|Norway|Poland|Russian Federation|Spain|Sweden|Ukraine	1
Denmark	1
Finland|Netherlands	1
Germany|Poland	1
Italy|United States|Canada|Greece|Hungary|Lithuania|Poland|Romania|Spain	1
Korea, Republic of	1
Poland	1
Poland|Australia|Austria|Czechia|New Zealand	1
Sweden	1
Switzerland	1
United States|Argentina	1
United States|Argentina|Chile|Costa Rica|Czech Republic|Estonia|Germany|India|Lithuania|Mexico|Poland|Russian Federation|Slovakia|	1
United States|Australia|Czechia|New Zealand|Poland|Spain|United Kingdom	1
United States|Belgium|Canada|Czechia|France|Germany|Hungary|Mexico|Poland|Portugal|Russian Federation|Spain|Ukraine|United Kingdom	1
United States|Belgium|Spain|Sweden	1
United States|Canada	1
United States|Canada|Czechia|Germany|Mexico|Poland|Portugal|Russian Federation|Ukraine|United Kingdom	1
United States|Canada|United Kingdom	1
United States|Czechia|Ukraine	1
United States|Poland	1
United States|United Kingdom	1

Sites per Study

Site_count	Study_Count
1	124
2	13
3	6
4	7
5	4
6	4
7	1
9	2
10	1
11	2
13	1
14	1
18	2
19	2
20	2
22	1
25	1
28	1
33	1
35	2
37	1
40	1
42	1
43	1
45	1
51	1
53	1
54	1
68	1
79	1
87	1
89	1

Phase

Phase	Study_Count
N/A	79
Phase 3	36
Phase 4	34
Phase 2	20
Phase 1/Phase 2	7
Phase 1	6
Early Phase 1	5
Phase 2/Phase 3	3

Number of Arms

Number_of_Arms	Count_of_Studies
1	39
2	109
3	18
4	7
5	1
13	1
NA	15

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	9	8.00000	6.00000	14.00000	5.00	40.00000	5.0000	14.0000
1st Qu.	20	30.00000	24.00000	21.00000	32.75	45.00000	59.7500	48.2500
Median	22	60.00000	38.50000	30.00000	60.00	50.00000	195.0000	83.0000
Mean	76	97.68831	40.83333	34.85714	140.15	63.33333	286.4444	149.7647
3rd Qu.	29	98.00000	44.00000	40.00000	100.00	75.00000	408.5000	189.0000
Max.	300	1000.00000	97.00000	78.00000	981.00	100.00000	981.0000	762.0000

Trial Group Type

group_type	Group_Count
Experimental	162
Active Comparator	104
Placebo Comparator	58
Other	15
NA	15
No Intervention	12
Sham Comparator	6

Intervention Model

intervention_model	Study_Count
Parallel Assignment	134
Single Group Assignment	48
Crossover Assignment	5
Factorial Assignment	1
Sequential Assignment	1
NA	1

Primary Purpose

primary_purpose	Study_Count
Treatment	152
Diagnostic	10
Prevention	7
Supportive Care	6
Other	5
NA	4
Basic Science	3
Device Feasibility	1
Educational/Counseling/Training	1
Health Services Research	1

Observational Studies

Studies by Country

Country	Study_Count
United States	24
NA	7
Germany	4
Thailand	2
United Kingdom	2
Austria|Bahrain|China|Egypt|France|Germany|Indonesia|Jordan|Kuwait|Lebanon|Malaysia|Netherlands|Pakistan|Philippines|Romania|Saudi Arabia|Singapore|United Arab Emirates|Yemen	1
Canada	1
Czechia	1
France	1
Korea, Republic of	1
Spain	1
United States|Australia	1

Sites per Study

Site_count	Study_Count
1	37
2	3
3	2
6	1
16	1
19	1
20	1

Enrollment Metrics

Measure	Observational
Min	12.000
1st Qu	33.000
Median	99.000
Mean	9619.689
3rd Qu	300.000
Max	239306.000

Observation Model

observational_model	Study_Count
Cohort	24
Case-Only	9
Case-Control	3
Case Control	3
Other	3
NA	2
Ecologic or Community	1
Family-Based	1

Time Perspective

time_perspective	Study_Count
Prospective	36
Cross-Sectional	4
Retrospective	4
NA	2

Registries

Studies by Country

Country	Study_Count
NA	1

Sites per Study

Site_count	Study_Count
1	1

Enrollment Metrics

Measure	Registries
Min	71
1st Qu	71
Median	71
Mean	71
3rd Qu	71
Max	71

Registry Model

observational_model	Study_Count
Cohort	1

Time Perspective

time_perspective	Study_Count
Prospective	1

Follow-up

target_duration	Study_Count
3 Years	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03390257	Study to Evaluate the Safety and Initial Effectiveness of the Sinuswayâ„¢ for Endoscopy of Sinuses in Conjunction With BSD	https://ClinicalTrials.gov/show/NCT03390257	Completed	3NT Medical Ltd.	2018-03-21
NCT03369717	Use of Perioperative Antibiotics in Endoscopic Sinus Surgery	https://ClinicalTrials.gov/show/NCT03369717	Recruiting	Montefiore Medical Center	2022-01-31
NCT03822962	Pain Management Following Sinus Surgery	https://ClinicalTrials.gov/show/NCT03822962	Recruiting	University of Nebraska	2020-12-31
NCT03336671	Management of Pediatric Chronic Rhinosinusitis in Asthmatic Children	https://ClinicalTrials.gov/show/NCT03336671	Recruiting	State University of New York - Upstate Medical University	2020-07-01
NCT03304951	Sinopsys® Lacrimal Stent Indicated for Sinus Irrigation	https://ClinicalTrials.gov/show/NCT03304951	Completed	Sinopsys Surgical	2016-08-31
NCT03280550	A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps	https://ClinicalTrials.gov/show/NCT03280550	Completed	Hoffmann-La Roche	2019-03-11
NCT03188822	Steroid Delivery to the Frontal Sinus Opening With a Bioabsorbable Implant vs. a Bioabsorbable Nasal Dressing	https://ClinicalTrials.gov/show/NCT03188822	Recruiting	University of Rochester	2020-12-31
NCT03122795	Sinonasal Microbiome Transplant as a Therapy for Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)	https://ClinicalTrials.gov/show/NCT03122795	Completed	Region Skane	2018-12-17
NCT03086070	Omeprazole 20 mg in Patients With Laryngopharyngeal reflux and Comorbid Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT03086070	Completed	Children’s Hospital Srebrnjak	2010-04-30
NCT03068728	Analysis of Hemostatic Agents Compared to Physiologic Hemostasis	https://ClinicalTrials.gov/show/NCT03068728	Completed	St. Louis University	2017-04-10
NCT02975310	In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps	https://ClinicalTrials.gov/show/NCT02975310	Recruiting	Ottawa Hospital Research Institute	2021-06-30
NCT02972281	Systematic Search for Primary Immunodeficiency in Adults With Infections	https://ClinicalTrials.gov/show/NCT02972281	Recruiting	University Hospital, Lille	2020-03-31
NCT02967731	480 Biomedical Sinus Drug Depot	https://ClinicalTrials.gov/show/NCT02967731	Completed	480 Biomedical	2017-12-19
NCT02927834	Oral Steroids in Chronic Rhinosinusitis Without Nasal Polyps	https://ClinicalTrials.gov/show/NCT02927834	Completed	Loma Linda University	2018-12-31
NCT02924103	Contamination Free Bacterial Swap	https://ClinicalTrials.gov/show/NCT02924103	Completed	Rigshospitalet, Denmark	2018-03-01
NCT02880514	In-office Placement of the Propel Mini Sinus Implant in the Frontal Sinus Ostia	https://ClinicalTrials.gov/show/NCT02880514	Completed	Intersect ENT	2016-12-31
NCT02874144	Anti-Inflammatory Agent in Sinusitis	https://ClinicalTrials.gov/show/NCT02874144	Enrolling by invitation	Northwestern University	2020-03-31
NCT02855931	Study to Compare Resection Versus Preservation of the Middle Turbinate in Surgery for Nasal Polyps	https://ClinicalTrials.gov/show/NCT02855931	Completed	Université de Sherbrooke	2017-12-31
NCT02077322	Rates of Middle Meatal Synechia Formation Following Functional Endoscopic Sinus Surgery	https://ClinicalTrials.gov/show/NCT02077322	Completed	St. Paul’s Hospital, Canada	2017-05-31
NCT02772419	Study of Benralizumab (KHK4563) in Patients With Eosinophilic Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT02772419	Completed	Kyowa Kirin Co., Ltd.	2017-03-27
NCT02748070	Perioperative Oral Steroids for Chronic Rhinosinusitis Without Polyps (CRSsNP)	https://ClinicalTrials.gov/show/NCT02748070	Completed	Stanford University	2019-07-31
NCT02746042	Sinupret Extract Coated Tablets in Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT02746042	Completed	Bionorica SE	2017-07-26
NCT02743871	Study Of PF-06817024 In Healthy Subjects, In Patients With Chronic Rhinosinusitis With Nasal Polyps And in Patients With Atopic Dermatitis	https://ClinicalTrials.gov/show/NCT02743871	Active, not recruiting	Pfizer	2021-02-14
NCT02696850	The Impact Of The Addition Of Budesonide To Low-Pressure, High-Volume Saline Sinus Irrigation For Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT02696850	Completed	Washington University School of Medicine	2017-04-13
NCT02687438	The PIO (Propel In Office) III Study of In-office Placement of a Steroid-Eluting Implant Immediately Following Ethmoid Sinus Surgery	https://ClinicalTrials.gov/show/NCT02687438	Completed	ENT and Allergy Associates, LLP	2016-02-29
NCT02668302	The PIO II Study: In-office Post-op Placement of a Steroid-eluting Sinus Implant	https://ClinicalTrials.gov/show/NCT02668302	Completed	Collin County Ear Nose & Throat	2016-11-30
NCT02582099	The Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis and Recurrent Sinusitis	https://ClinicalTrials.gov/show/NCT02582099	Recruiting	Mahidol University	2019-06-30
NCT02562924	The Efficacy of MEDIHONEY® for Chronic Rhinosinusitis With Nasal Polyposis After Functional Endoscopic Sinus Surgery	https://ClinicalTrials.gov/show/NCT02562924	Completed	University of Vermont Medical Center	2017-12-31
NCT02533206	Pilot Study of The EPIC Trial	https://ClinicalTrials.gov/show/NCT02533206	Active, not recruiting	Ottawa Hospital Research Institute	2021-06-30
NCT02502084	Safety and Effectiveness Evaluation of the Sinusway Device for Endoscopy of the Nasal Cavity and Paranasal Sinuses	https://ClinicalTrials.gov/show/NCT02502084	Completed	3NT Medical Ltd.	2017-04-30
NCT02463279	SinuSys Patency of Frontal Recess and Sphenoid Sinus Ostia Study	https://ClinicalTrials.gov/show/NCT02463279	Completed	SinuSys Corporation	2015-10-31
NCT02403479	The Effectiveness of Topical Silver Colloid in Treating Patients With Recalcitrant Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT02403479	Completed	Lawson Health Research Institute	2016-03-06
NCT02340000	Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate	https://ClinicalTrials.gov/show/NCT02340000	Completed	Albany Medical College	2017-02-27
NCT02307825	Azithromycin for Patients With Chronic Rhinosinusitis Failing Medical and Surgical Therapy	https://ClinicalTrials.gov/show/NCT02307825	Completed	Centre hospitalier de l’Université de Montréal (CHUM)	2017-08-15
NCT02297243	Sinopsys Lacrimal Stent Indicated for Sinus Irrigation	https://ClinicalTrials.gov/show/NCT02297243	Completed	Sinopsys Surgical	2016-02-29
NCT02296814	Efficacy and Safety of Sinusitis Hevert SL Tablets Compared to Placebo in Adult Patients With Acute, Uncomplicated Rhinosinusitis	https://ClinicalTrials.gov/show/NCT02296814	Completed	Hevert-Arzneimittel GmbH & Co. KG	2015-04-30
NCT02291549	S8 Sinus Implant in Chronic Sinusitis Patients With Recurrent Nasal Polyps	https://ClinicalTrials.gov/show/NCT02291549	Completed	Intersect ENT	2016-10-31
NCT02228720	Clinical Evaluation of Propel Nova Sinus Implant in Peripheral Sinus Ostia	https://ClinicalTrials.gov/show/NCT02228720	Completed	Intersect ENT	2014-10-31
NCT02194062	Comparison of Nasal Steroids After FESS in CRSwNP	https://ClinicalTrials.gov/show/NCT02194062	Completed	Yale University	2015-07-31
NCT02191046	Effect of Squeezable Bottle Nasal Irrigation Device in Children With Sinusitis	https://ClinicalTrials.gov/show/NCT02191046	Completed	Thammasat University	2014-05-31
NCT02182492	Efficacy of Macrolide and Glucocorticoid in the Treatment of Chronic Rhinosinusitis After Endoscopic Sinus Surgery	https://ClinicalTrials.gov/show/NCT02182492	Completed	Huazhong University of Science and Technology	2015-12-31
NCT02170337	A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 282 in Healthy Subjects and Subjects With Chronic Rhinosinusitis With Nasal Polyps	https://ClinicalTrials.gov/show/NCT02170337	Completed	Amgen	2016-05-31
NCT02079792	The Optimal Head Position for Distributing Topical Nasal Medication Using the Mucosal Atomization Device	https://ClinicalTrials.gov/show/NCT02079792	Completed	St. Paul’s Hospital, Canada	2015-06-30
NCT03358329	Safety Evaluation of Repeat Placement of the S8 Sinus Implant in Chronic Sinusitis Patients With Nasal Polyps (ENCORE)	https://ClinicalTrials.gov/show/NCT03358329	Completed	Intersect ENT	2019-01-17
NCT01990820	Study for the Management of Pediatric Chronic Rhinosinusitis With or Without Balloon Sinuplasty	https://ClinicalTrials.gov/show/NCT01990820	Completed	NorthShore University HealthSystem	2016-09-29
NCT01988779	Oral Versus Topical Antibiotics for Chronic Rhinosinusitis Exacerbations	https://ClinicalTrials.gov/show/NCT01988779	Active, not recruiting	University of Rochester	2017-09-11
NCT04420052	Effects of Osteopathic Manipulative Treatment in Chronic Non-allergic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT04420052	Recruiting	Institut des Hautes Etudes Osteopathiques de Nantes	2021-06-01
NCT01934231	Study to Assess the Efficacy and Safety of Potassium Clavulanate/Amoxicillin in Children With Acute Bacterial Rhinosinusitis	https://ClinicalTrials.gov/show/NCT01934231	Completed	GlaxoSmithKline	2013-11-07
NCT01919411	Prophylactic Antibiotics After Functional Endoscopic Sinus Surgery: a Randomized, Double-blind Placebo Controlled Trial	https://ClinicalTrials.gov/show/NCT01919411	Completed	Massachusetts Eye and Ear Infirmary	2018-09-30
NCT01907204	Evaluation of Inhaled Treatment in Sinusitis	https://ClinicalTrials.gov/show/NCT01907204	Completed	Cliniques universitaires Saint-Luc- Université Catholique de Louvain	2013-08-31
NCT01894503	Safety and Performance of the Steroid-Releasing S8 Sinus Implant	https://ClinicalTrials.gov/show/NCT01894503	Completed	Intersect ENT	2013-10-31
NCT01825408	Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT01825408	Completed	University of North Carolina, Chapel Hill	2014-06-30
NCT01806103	Antimicrobial Stewardship for Primary Care Pediatricians	https://ClinicalTrials.gov/show/NCT01806103	Completed	Children’s Hospital of Philadelphia	2011-06-30
NCT01732536	Steroid-Releasing S8 Sinus Implant for Recurrent Nasal Polyps	https://ClinicalTrials.gov/show/NCT01732536	Completed	Intersect ENT	2013-11-30
NCT01717274	Hot Saline Irrigation Study	https://ClinicalTrials.gov/show/NCT01717274	Completed	St. Paul’s Hospital, Canada	2015-03-31
NCT01714687	Comparison of Balloon Sinuplasty In-Office Versus Medical Management for Recurrent Acute Sinusitis Patients (CABERNET)	https://ClinicalTrials.gov/show/NCT01714687	Completed	Acclarent	2015-10-01
NCT01706952	Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery	https://ClinicalTrials.gov/show/NCT01706952	Completed	McGill University Health Centre/Research Institute of the McGill University Health Centre	2013-12-31
NCT01706484	Efficacy and Safety of Two Dosages of a Herbal Medicinal Product (Dry Extract BNO 1016) in Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT01706484	Completed	Bionorica SE	2014-04-30
NCT01700725	Gulf War Illness Nasal Irrigation Study	https://ClinicalTrials.gov/show/NCT01700725	Completed	University of Wisconsin, Madison	2016-06-30
NCT01691677	beCLomethasone Efficacy in Acute Rhinosinusitis - CLEAR Study	https://ClinicalTrials.gov/show/NCT01691677	Completed	Chiesi Farmaceutici S.p.A.	2014-01-31
NCT04085536	Prospective Study on the Efficacy of Exclusive Odontological and Medical Treatment in Chronic Dental Maxillary Sinusitis	https://ClinicalTrials.gov/show/NCT04085536	Recruiting	Centre Hospitalier Intercommunal Creteil	2021-10-15
NCT01623323	Study Evaluating the Safety of Intranasal Administration of 400 μg of Fluticasone Propionate Twice a Day (BID) Using a Novel Bi-Directional Device in Subjects With Chronic Sinusitis With or Without Nasal Polyps	https://ClinicalTrials.gov/show/NCT01623323	Completed	Optinose US Inc.	2015-03-31
NCT01623050	Safety and Performance of the SinuSys Dilation System for Dilation of the Maxillary Sinus Ostium	https://ClinicalTrials.gov/show/NCT01623050	Completed	SinuSys Corporation	2013-06-30
NCT01612780	Trans-Nasal Maxillary Multi-Sinus Balloon Dilation Study	https://ClinicalTrials.gov/show/NCT01612780	Completed	Entellus Medical, Inc.	2013-10-31
NCT01608308	Intraoperative and Post-operative Analgesic Effect of IV Acetaminophen for Sinus Surgery	https://ClinicalTrials.gov/show/NCT01608308	Completed	The University of Texas Health Science Center, Houston	2014-09-30
NCT01575223	Saline Irrigation After Surgery in Patients With Chronic Sinusitis	https://ClinicalTrials.gov/show/NCT01575223	Completed	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	2014-04-30
NCT01569048	Randomized Controlled Trial to Evaluate of Dexmedetomidine for the Effect on Operative Visibility in Patients Undergoing Endoscopic Sinus Surgery	https://ClinicalTrials.gov/show/NCT01569048	Completed	Yonsei University	2014-02-28
NCT01564355	Postoperative Systemic Corticosteroids When Utilizing a Steroid-Eluting Spacer Following Endoscopic Sinus Surgery	https://ClinicalTrials.gov/show/NCT01564355	Completed	University of Calgary	2013-09-30
NCT01525862	XprESS Maxillary Balloon Dilation Study	https://ClinicalTrials.gov/show/NCT01525862	Completed	Entellus Medical, Inc.	2013-01-31
NCT01525849	Randomized Evaluation of Maxillary Antrostomy Versus Ostial Dilation Efficacy Through Long-Term Follow-Up	https://ClinicalTrials.gov/show/NCT01525849	Completed	Entellus Medical, Inc.	2014-02-28
NCT01442740	15-Degree Tilt, Head Up, Feet Down Body Position for Sinus Surgery Patients	https://ClinicalTrials.gov/show/NCT01442740	Completed	St. Paul’s Hospital, Canada	2012-03-31
NCT01420471	Medicated Punctured-Glove-Finger Spacer Study	https://ClinicalTrials.gov/show/NCT01420471	Completed	St. Paul’s Hospital, Canada	2012-05-31
NCT01405339	Budesonide Application Via Mucosal Atomization Device as a Treatment for Chronic Rhinosinusitis When Utilized as a Topical Nasal Steroid Spray	https://ClinicalTrials.gov/show/NCT01405339	Completed	St. Paul’s Hospital, Canada	2013-05-31
NCT01350193	Manuka Honey Irrigation After Sinus Surgery	https://ClinicalTrials.gov/show/NCT01350193	Completed	St. Paul’s Hospital, Canada	2013-01-31
NCT04291118	Assessing Improvement in Cognitive Deficit in CRS in Patients Treated With Medical Vs Surgical Management	https://ClinicalTrials.gov/show/NCT04291118	Recruiting	St. Paul’s Hospital, Canada	2021-09-01
NCT04286542	Mediators in Nasal Hyperreactivity in Allergic Rhinitis and Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT04286542	Recruiting	Universitaire Ziekenhuizen Leuven	2021-12-31
NCT04241016	Endoscopic Sinus Surgery in Recurrent Acute Rhinosinusitis	https://ClinicalTrials.gov/show/NCT04241016	Recruiting	Oulu University Hospital	2024-12-31
NCT04171167	The Causal Relation of Nasal Nitric Oxide Levels to the Severity of Chronic Rhinosinusitis and Its Inflammatory Phenotype	https://ClinicalTrials.gov/show/NCT04171167	Recruiting	Tampere University Hospital	2020-12-31
NCT04163978	Nitric Oxide Releasing Sinus Irrigation (NOSi) to Treat Recalcitrant Chronic Rhinosinusitis (RCRS)	https://ClinicalTrials.gov/show/NCT04163978	Recruiting	Sanotize Research and Development corp.	2020-04-30
NCT04104594	Olfaction and Inflammation in Chronic Rhinosinusitis With Nasal Polyps	https://ClinicalTrials.gov/show/NCT04104594	Recruiting	Centre Hospitalier Universitaire de Saint Etienne	2020-10-31
NCT04097613	Betadine Rinses for Chronic Rhinosinusitis Prospective Cohort Study	https://ClinicalTrials.gov/show/NCT04097613	Completed	St. Paul’s Hospital, Canada	2019-04-01
NCT04093193	Debridement and Functional Endoscopic Sinus Surgery	https://ClinicalTrials.gov/show/NCT04093193	Recruiting	St. Paul’s Hospital, Canada	2021-07-01
NCT04048174	Safety and Efficacy of Lactococcus Lactis Probiotic Bacteria for the Treatment of Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT04048174	Completed	Centre hospitalier de l’Université de Montréal (CHUM)	2015-12-02
NCT04048070	The Effect of Enhanced Recovery After Surgery in Endoscopic Sinus Surgery	https://ClinicalTrials.gov/show/NCT04048070	Completed	Beijing Tongren Hospital	2018-10-15
NCT04041609	LYR-210 Depot (LYR-210) for Adult Subjects With Chronic Sinusitis (LANTERN Study)	https://ClinicalTrials.gov/show/NCT04041609	Active, not recruiting	Lyra Therapeutics	2020-09-30
NCT03229551	Xylitol for Chronic Sinusitis	https://ClinicalTrials.gov/show/NCT03229551	Recruiting	Ochsner Health System	2020-02-29
NCT03979209	Potential for Cortisol Suppression With the Use of High Volume Nasal Mometasone Irrigations in Varying Dosages.	https://ClinicalTrials.gov/show/NCT03979209	Recruiting	Rush University Medical Center	2019-08-23
NCT03970655	Functional Endoscopic Sinus Surgery Study	https://ClinicalTrials.gov/show/NCT03970655	Recruiting	University of Florida	2021-07-31
NCT03960580	Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Sinusitis Without the Presence of Nasal Polyps	https://ClinicalTrials.gov/show/NCT03960580	Recruiting	Optinose US Inc.	2021-04-30
NCT03956862	GB001 in Adult Subjects With Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT03956862	Active, not recruiting	Gossamer Bio Inc.	2020-07-31
NCT03943121	The Effects of Steroid-eluting Stent Implant for the Treatment of Eosinophilic Chronic Rhinosinusitis With Nasal Polyps	https://ClinicalTrials.gov/show/NCT03943121	Recruiting	Beijing Tongren Hospital	2019-09-01
NCT03878355	A Study of Different Endoscopic Surgery Procedures in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps	https://ClinicalTrials.gov/show/NCT03878355	Completed	Beijing Tongren Hospital	2013-10-31
NCT03815435	The Influence of Blood Pressure Upon the Clarity of Surgical Field in Endonasal Surgery	https://ClinicalTrials.gov/show/NCT03815435	Completed	University Hospital Ostrava	2020-01-31
NCT03809312	The Use of Prophylactic Antibiotics in Endoscopy Sinus Surgery for Chronic Rhinosinusitis With or Without Polyp	https://ClinicalTrials.gov/show/NCT03809312	Recruiting	CHU de Quebec-Universite Laval	2020-12-31
NCT03783702	Pain Control Following Sinus Surgery	https://ClinicalTrials.gov/show/NCT03783702	Recruiting	Stanford University	2019-10-01
NCT03781804	Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Sinusitis With or Without the Presence of Nasal Polyps	https://ClinicalTrials.gov/show/NCT03781804	Recruiting	Optinose US Inc.	2020-12-31
NCT03766568	Single Use Device Endoscopy for the Diagnosis of Acute Bacterial Rhinosinusitis in Primary Care	https://ClinicalTrials.gov/show/NCT03766568	Recruiting	Basel Institute for Clinical Epidemiology and Biostatistics	2020-05-31
NCT03729258	Efficacy and Safety of Modified Release Cefpodoxime Formulation in the Treatment of Acute Sinusitis.	https://ClinicalTrials.gov/show/NCT03729258	Recruiting	Neutec Ar-Ge San ve Tic A.Åž	2020-10-01
NCT03705793	Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT03705793	Completed	Washington University School of Medicine	2020-02-15
NCT03704415	Aggravated Airway Inflammation: Research on Genomics and Optimal Operative Treatment (AirGOs Operative)	https://ClinicalTrials.gov/show/NCT03704415	Recruiting	Helsinki University Central Hospital	2023-12-31
NCT03687515	Efficacy and Safety of Budesonide Inhalation Suspension for the Treatment of Chronic Rhinosinusitis With Polyposis.	https://ClinicalTrials.gov/show/NCT03687515	Completed	Beijing Tongren Hospital	2016-12-03
NCT03675022	Effect of Dupilumab on Sleep Apnea in Patients With Rhinosinusitis	https://ClinicalTrials.gov/show/NCT03675022	Recruiting	Brigham and Women’s Hospital	2020-07-31
NCT03673956	Topical Antibiotics in Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT03673956	Recruiting	Mayo Clinic	2020-12-01
NCT03661346	Esmolol vs. Labetalol in Endoscopic Sinus Surgery	https://ClinicalTrials.gov/show/NCT03661346	Completed	The University of Texas Medical Branch, Galveston	2018-03-30
NCT03614923	Etokimab in Adult Patients With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)	https://ClinicalTrials.gov/show/NCT03614923	Active, not recruiting	AnaptysBio, Inc.	2020-09-30
NCT03584178	The Long-Term Safety of Budesonide for Patients With Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT03584178	Recruiting	St. Paul’s Hospital, Canada	2020-12-25
NCT03478930	An Extension Study of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps	https://ClinicalTrials.gov/show/NCT03478930	Completed	Hoffmann-La Roche	2020-03-16
NCT03450083	Benralizumab Effect on Severe Chronic Rhinosinusitis With Eosinophilic Polyposis	https://ClinicalTrials.gov/show/NCT03450083	Completed	Johns Hopkins University	2020-01-01
NCT03439865	Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT03439865	Recruiting	University of Alabama at Birmingham	2021-05-31
NCT03431337	Treatment of Acute Sinusitis With High-Dose vs. Standard-Dose Amoxicillin/Clavulanate	https://ClinicalTrials.gov/show/NCT03431337	Recruiting	Albany Medical College	2021-03-31
NCT01253577	A Clinical Evaluation of a Steroid-Coated Sinus Stent When Used Following Functional Endoscopic Sinus Surgery in Patients With Chronic Sinusitis	https://ClinicalTrials.gov/show/NCT01253577	Completed	Intersect ENT	2010-10-31
NCT01205984	Systemic Methylprednisolone in Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT01205984	Completed	Ondokuz Mayıs University	2009-09-30
NCT01198912	Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial	https://ClinicalTrials.gov/show/NCT01198912	Completed	University Hospital, Ghent	2016-09-06
NCT01179139	Pathogenesis of Chronic Sinusitis in Relationship to Tobacco Smoke Exposure	https://ClinicalTrials.gov/show/NCT01179139	Completed	Massachusetts General Hospital	2010-07-31
NCT01166945	Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children	https://ClinicalTrials.gov/show/NCT01166945	Completed	University of Wisconsin, Madison	2016-02-29
NCT01146860	Efficacy and Safety of a Herbal Medicinal Product (Dry Extract BNO 1016) in Patients With Acute Rhinosinusitis	https://ClinicalTrials.gov/show/NCT01146860	Completed	Bionorica SE	2010-04-30
NCT01197612	Nasal Packing as a Drug Delivery System Postoperatively in Chronic Sinusitis With Polyposis	https://ClinicalTrials.gov/show/NCT01197612	Completed	University of Michigan	2012-06-30
NCT01118312	Study of Asthma and Nasal Steroids	https://ClinicalTrials.gov/show/NCT01118312	Completed	JHSPH Center for Clinical Trials	2014-06-30
NCT01115309	XprESS Registry Study	https://ClinicalTrials.gov/show/NCT01115309	Completed	Entellus Medical, Inc.	2011-12-31
NCT01111669	Intravenous Tranexamic Acid and Intraoperative Visualization During Functional Endoscopic Sinus Surgery	https://ClinicalTrials.gov/show/NCT01111669	Completed	University of Alberta	2011-12-31
NCT01086839	Sino-nasal Inhalation of Sodium Chloride 6,0% in Patients With Cystic Fibrosis and Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT01086839	Completed	University of Jena	2013-04-30
NCT01066104	Subcutaneous Omalizumab for Treatment of Chronic Rhinosinusitis With Nasal Polyposis	https://ClinicalTrials.gov/show/NCT01066104	Completed	Massachusetts General Hospital	2015-07-31
NCT01050465	MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use	https://ClinicalTrials.gov/show/NCT01050465	Completed	University of Missouri-Columbia	2010-10-31
NCT01033799	Effect of the Consumption of a Fermented Milk on Common Infections in Shift-workers	https://ClinicalTrials.gov/show/NCT01033799	Completed	Danone Research	2007-04-30
NCT01018030	Dose Finding Study of Fluticasone Furoate Nasal Spray for Uncomplicated Acute Rhinosinusitis	https://ClinicalTrials.gov/show/NCT01018030	Completed	GlaxoSmithKline	2010-07-01
NCT01007799	Vitamin D for Chronic Sinusitis	https://ClinicalTrials.gov/show/NCT01007799	Completed	University of Chicago	2011-09-30
NCT00947986	Mucociliary Clearance Time in Chronic Rhinosinusitis (CRS) Patients After Sinus Surgery	https://ClinicalTrials.gov/show/NCT00947986	Completed	The University of Texas Health Science Center, Houston	2010-02-28
NCT00944515	Efficacy of Azithromycin Prophylaxis in Preventing Recurrent Acute Sinusitis in Children	https://ClinicalTrials.gov/show/NCT00944515	Completed	Mahidol University	2015-12-31
NCT00939471	Safety and Efficacy of Balloon Sinuplasty in Pediatric Sinusitis	https://ClinicalTrials.gov/show/NCT00939471	Completed	Acclarent	2009-07-01
NCT00939393	Balloon Sinus Dilation In Office or OR	https://ClinicalTrials.gov/show/NCT00939393	Completed	Acclarent	2009-06-01
NCT00934830	Antibiotics Versus Therapeutic Ultrasound for Sinusitis	https://ClinicalTrials.gov/show/NCT00934830	Completed	Norwegian University of Science and Technology	2008-10-31
NCT00924404	Xylitol Versus Saline in Chronic Sinusitis	https://ClinicalTrials.gov/show/NCT00924404	Completed	University of Iowa	2014-08-31
NCT00912405	Clinical Evaluation of the Steroid-Eluting Sinexus Intranasal Splint When Used Following Functional Endoscopic Sinus Surgery (FESS) in Patients With Chronic Sinusitis	https://ClinicalTrials.gov/show/NCT00912405	Completed	Intersect ENT	2009-06-30
NCT00871286	Point-of-Care Computed Tomography (CT) Chronic Rhinosinusitis Study	https://ClinicalTrials.gov/show/NCT00871286	Completed	Northwestern University	2010-08-31
NCT03154541	SynRinse Irrigation Pilot (SIP) Trial	https://ClinicalTrials.gov/show/NCT03154541	Completed	University of Washington	2018-05-30
NCT01920893	An Evaluation of Dupilumab in Patients With Nasal Polyposis And Chronic Symptoms Of Sinusitis	https://ClinicalTrials.gov/show/NCT01920893	Completed	Sanofi	2014-11-30
NCT03011632	Response of the Airway in Sinusitis and Asthma	https://ClinicalTrials.gov/show/NCT03011632	Completed	Medical Universtity of Lodz	2019-08-31
NCT02888730	Tobramycin Delivered by Nebulized Sonic Aerosol for Chronic Rhinosinusitis Treatment of Cystic Fibrosis Patients	https://ClinicalTrials.gov/show/NCT02888730	Recruiting	Centre Hospitalier Intercommunal Creteil	2022-01-31
NCT02278484	Sinus Balloon Dilation in Pediatric Patients	https://ClinicalTrials.gov/show/NCT02278484	Completed	Entellus Medical, Inc.	2015-09-30
NCT02217332	Study of Dexpramipexole Chronic Sinusitis With Nasal Polyps and Eosinophilia	https://ClinicalTrials.gov/show/NCT02217332	Completed	Knopp Biosciences	2016-12-14
NCT02106793	Mitomicin C for Prevention Postoperative Endoscopic Sinus Surgery Synechia and QOL in Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT02106793	Completed	Mahidol University	2017-12-01
NCT00896883	Evaluation of the Middle Turbinate Implant for Affixing the Middle Turbinate to the Nasal Septum	https://ClinicalTrials.gov/show/NCT00896883	Completed	ENTrigue Surgical, Inc.	2009-11-30
NCT02266810	Safety and Efficacy of the Propel Mini and Propel Nova Steroid-Eluting Sinus Implant in Frontal Sinus	https://ClinicalTrials.gov/show/NCT02266810	Completed	Intersect ENT	2016-04-30
NCT00791934	Clinical Study of Safety and Efficacy for the Relieva Stratus With Elution of Triamcinolone Acetonide	https://ClinicalTrials.gov/show/NCT00791934	Completed	Acclarent	2011-11-30
NCT00751075	Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Phase 3 Study)(Study P02692)	https://ClinicalTrials.gov/show/NCT00751075	Completed	Merck Sharp & Dohme Corp.	2004-05-06
NCT00750750	Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Study P02683)	https://ClinicalTrials.gov/show/NCT00750750	Completed	Merck Sharp & Dohme Corp.	2003-09-01
NCT00747747	Sinuclean’s Treatment Of Sinusitis’ Symptoms	https://ClinicalTrials.gov/show/NCT00747747	Completed	Galsor S.r.l.	2009-01-31
NCT00739921	The Polymerase Chain Reaction (PCR) Analysis of Nasal Polyps for Fungal DNA	https://ClinicalTrials.gov/show/NCT00739921	Completed	University of California, San Francisco	2015-05-31
NCT00683371	Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT00683371	Completed	University of California, San Francisco	2008-04-30
NCT00668304	Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox	https://ClinicalTrials.gov/show/NCT00668304	Completed	Bayer	NA
NCT00645762	Balloon REmodeling Antrostomy THErapy Study	https://ClinicalTrials.gov/show/NCT00645762	Completed	Entellus Medical, Inc.	2010-06-30
NCT00645073	Study of the Safety and Efficacy of Cefdinir and Levofloxacin for the Treatment of Subjects With Acute Bacterial Sinusitis	https://ClinicalTrials.gov/show/NCT00645073	Completed	Abbott	2004-03-31
NCT00644553	Comparative Study of the Safety and Efficacy of Clarithromycin Extended-Release Tablets Versus Amoxicillin-Clavulanate for the Treatment of Acute Bacterial Sinusitis	https://ClinicalTrials.gov/show/NCT00644553	Completed	Abbott	2004-03-31
NCT00643409	A Multicenter, Randomized, Double-Blind, Double-Dummy Trial of Azithromycin SR Compared With Levofloxacin for the Treatment of Sinus Infections in Adults	https://ClinicalTrials.gov/show/NCT00643409	Completed	Pfizer	NA
NCT00634608	Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow	https://ClinicalTrials.gov/show/NCT00634608	Completed	University of Missouri-Columbia	2009-03-31
NCT00626366	Distribution of Topical Nasal Medication Within the Nasal Cavity and Sinuses by Radiographic Comparison	https://ClinicalTrials.gov/show/NCT00626366	Completed	University of Nebraska	2009-01-31
NCT00610779	Treatment of Acute Rhino-Sinusitis With Essential Oils of Aromatic Plants	https://ClinicalTrials.gov/show/NCT00610779	Completed	HaEmek Medical Center, Israel	2008-05-31
NCT00588016	Concentration of Itraconazole Solution in Nasal Secretions	https://ClinicalTrials.gov/show/NCT00588016	Completed	Mayo Clinic	2013-12-31
NCT00554190	Study to Evaluate Safety and Effectiveness of AdvaCoat Sinus Gel	https://ClinicalTrials.gov/show/NCT00554190	Completed	Carbylan Therapeutics, Inc.	2007-12-31
NCT00552773	Pilot Study to Determine Efficacy of Cyclamen Europaeum Extract Nasal Spray in Patients With Acute Sinusitis	https://ClinicalTrials.gov/show/NCT00552773	Completed	Dey	2008-09-30
NCT00537563	AMS VS MOXI Ketek vs Avelox in AMS	https://ClinicalTrials.gov/show/NCT00537563	Completed	Sanofi	2003-09-30
NCT00534768	Postoperative Treatment After Endoscopic Sinus Surgery	https://ClinicalTrials.gov/show/NCT00534768	Completed	Kuopio University Hospital	NA
NCT00534079	Nasal Inhalation of Pulmozyme in Patients With Cystic Fibrosis and Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT00534079	Completed	University of Jena	2009-02-28
NCT00492024	BAY12-8039: 5 Days for Sinusitis vs Placebo	https://ClinicalTrials.gov/show/NCT00492024	Completed	Bayer	2008-03-31
NCT00465530	Comparing the Use of Saline or Saline Plus Gentamycin in Nasal Irrigation to Treat Chronic Sinusitis in Children	https://ClinicalTrials.gov/show/NCT00465530	Completed	University of Kansas Medical Center	2010-03-31
NCT00447837	Evaluating SPRC-AB01 in Post-Surgical Subjects With Chronic Sinusitis	https://ClinicalTrials.gov/show/NCT00447837	Completed	Naryx Pharma	2007-12-31
NCT00425620	Amphotericin B Suspension in Refractory Chronic Sinusitis	https://ClinicalTrials.gov/show/NCT00425620	Completed	Accentia Biopharmaceuticals	NA
NCT00416182	Nasally Delivered Pulmozyme for Sinusitis in Cystic Fibrosis	https://ClinicalTrials.gov/show/NCT00416182	Completed	University of Vermont	2012-06-30
NCT00410735	Study of ONO-1078 in Patients With Chronic Sinusitis	https://ClinicalTrials.gov/show/NCT00410735	Completed	Ono Pharmaceutical Co. Ltd	2008-06-30
NCT00396162	Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT00396162	Completed	University of Michigan	2008-01-31
NCT00377403	Treatment of Acute Sinusitis	https://ClinicalTrials.gov/show/NCT00377403	Completed	Washington University School of Medicine	2009-05-31
NCT00368823	A Trial of Point of Care Information in Ambulatory Pediatrics	https://ClinicalTrials.gov/show/NCT00368823	Completed	University of Washington	NA
NCT00367120	Zmax Compared to Augmentin in Sinusitis	https://ClinicalTrials.gov/show/NCT00367120	Completed	Pfizer	NA
NCT00335309	Maxillary Sinus Irrigation in the Management of Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT00335309	Completed	Carmel Medical Center	2013-08-31
NCT00265434	Nasal Inhalation of Dornase Alfa (Pulmozyme) in Patients With Cystic Fibrosis and Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT00265434	Completed	University of Jena	2006-05-31
NCT00249210	A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the Treatment of Adults With Rapid Onset of Severe Inflammation/Infection of the Sinuses	https://ClinicalTrials.gov/show/NCT00249210	Completed	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	NA
NCT00245427	Outcomes of Patients Not Responding to Antibiotics in the Community	https://ClinicalTrials.gov/show/NCT00245427	Completed	CPL Associates	NA
NCT00242437	Hemostatic Matrix in Endoscopic Sinus Surgery	https://ClinicalTrials.gov/show/NCT00242437	Completed	Ethicon, Inc.	NA
NCT00236652	A Study Evaluating the Safety and Efficacy of Treating Sinus Infection With Levofloxacin 750 mg for 5 Days.	https://ClinicalTrials.gov/show/NCT00236652	Completed	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	NA
NCT00236522	A Comparison of the Safety and Efficacy of Two Different Regimens of Levofloxacin in the Treatment of Acute Bacterial Sinusitis(Sinus Infection) in Adults.	https://ClinicalTrials.gov/show/NCT00236522	Completed	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	NA
NCT00232154	A Study To Measure The Level Of Drug In Nasal Tissue And Blood After Taking A Single 2g Dose Or 500mg Tablets For Up To	https://ClinicalTrials.gov/show/NCT00232154	Completed	Pfizer	2006-06-30
NCT00231062	Clinical Evaluation to Confirm Safety and Efficacy of Sinuplasty in the Paranasal Sinuses (CLEAR)	https://ClinicalTrials.gov/show/NCT00231062	Completed	Acclarent	2006-06-30
NCT00208065	Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers	https://ClinicalTrials.gov/show/NCT00208065	Completed	Clinvest	2005-11-30
NCT00184392	Cleaning of the Nose After Sinus Surgery: Necessary or Only Bothersome?	https://ClinicalTrials.gov/show/NCT00184392	Completed	Norwegian University of Science and Technology	2005-12-31
NCT00174694	CHOOSE : Telithromycin, Acute Bacterial Sinusitis	https://ClinicalTrials.gov/show/NCT00174694	Completed	Sanofi	2005-12-31
NCT00147914	Comparison Study Between Cefdinir & Amoxicilline/Clavulanate in Acute Sinusitis and Assessment of Quality of Life	https://ClinicalTrials.gov/show/NCT00147914	Completed	University of Chicago	2007-02-28
NCT00132275	Guidelines for Acute Sinusitis	https://ClinicalTrials.gov/show/NCT00132275	Completed	University of Pittsburgh	NA
NCT00117611	Xolair in Patients With Chronic Sinusitis	https://ClinicalTrials.gov/show/NCT00117611	Completed	University of Chicago	2007-05-31
NCT00002149	Acupuncture and Herbal Treatment of Chronic HIV Sinusitis	https://ClinicalTrials.gov/show/NCT00002149	Completed	NIH AIDS Clinical Trials Information Service	NA
NCT00004638	Immunologic Aspects of the Pathogenesis of Chronic Sinusitis in Children	https://ClinicalTrials.gov/show/NCT00004638	Completed	National Center for Research Resources (NCRR)	NA

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03250429	Nasal and Peripheral Blood Biomarkers of CRS Patients Before and After Surgical Intervention	https://ClinicalTrials.gov/show/NCT03250429	Completed	University of North Carolina, Chapel Hill	2018-12-10
NCT02720653	Determinants of Olfactory Dysfunction in Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT02720653	Enrolling by invitation	Oregon Health and Science University	2021-06-30
NCT02712502	Levofloxacin in Bacterial Rhinosinussitis	https://ClinicalTrials.gov/show/NCT02712502	Completed	Dr. Reddy’s Laboratories Limited	2014-12-31
NCT02038166	Nasal Potential Difference (NPD) Protocol in Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT02038166	Recruiting	University of Alabama at Birmingham	2020-07-31
NCT02548598	Analysis of Inflammation and Microbiome in Patients With Sinusitis and Asthma	https://ClinicalTrials.gov/show/NCT02548598	Active, not recruiting	University of California, San Francisco	2017-09-30
NCT02297815	Comparative Effectiveness of Antibiotics for Respiratory Infections	https://ClinicalTrials.gov/show/NCT02297815	Completed	Children’s Hospital of Philadelphia	2016-04-30
NCT02270125	Nanoparticles in Nasal Mucosa	https://ClinicalTrials.gov/show/NCT02270125	Completed	University Hospital Ostrava	2017-11-30
NCT02221128	PerClot to Control Bleeding in Endoscopic Sinus Surgery	https://ClinicalTrials.gov/show/NCT02221128	Completed	CryoLife Europa	2014-09-30
NCT01827176	Clinical Characteristic of Recurrent Acute Rhinosinusitis in Children	https://ClinicalTrials.gov/show/NCT01827176	Completed	Mahidol University	2014-04-30
NCT01685229	Medical Therapy Versus Balloon Sinus Dilation for Patients With Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT01685229	Completed	Acclarent	2015-04-01
NCT01684540	Application of Ectoin® Rhinitis Nasal Spray in Patients With Acute Rhinosinusitis	https://ClinicalTrials.gov/show/NCT01684540	Completed	Bitop AG	2012-08-31
NCT01671098	Sinonasal Gas Exchange Dynamics	https://ClinicalTrials.gov/show/NCT01671098	Completed	Louisiana State University Health Sciences Center Shreveport	2015-08-31
NCT01553110	An Observational Study to Evaluate The Relationship of Nasal Mucus Properties and Symptoms	https://ClinicalTrials.gov/show/NCT01553110	Completed	Virginia Commonwealth University	2018-12-31
NCT01513837	Rinitis y Sinusitis según la Gravedad Del Asma	https://ClinicalTrials.gov/show/NCT01513837	Completed	Fundació Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau	2012-02-29
NCT01492868	Sinusitis in Children and the Nasopharyngeal Microbiome	https://ClinicalTrials.gov/show/NCT01492868	Completed	University of Wisconsin, Madison	2017-06-30
NCT01430026	Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT01430026	Completed	Mahidol University	2012-01-31
NCT01402349	Chronic Rhinosinusitis in a Danish Population: Evaluation of Causes of Disease, Progress and Treatment	https://ClinicalTrials.gov/show/NCT01402349	Completed	Odense University Hospital	2011-04-30
NCT01332136	Determinants of Medical and Surgical Treatment Outcomes in Chronic Sinusitis	https://ClinicalTrials.gov/show/NCT01332136	Completed	Oregon Health and Science University	2016-03-31
NCT04131686	NAC Inhalation in the Treatment Of Symptomatic acuTe rhinosinUSitis	https://ClinicalTrials.gov/show/NCT04131686	Recruiting	Boryung Pharmaceutical Co., Ltd	2021-05-30
NCT03975842	Chronic Otitis Media With Effusion in Chronic Sinusitis With Polyps	https://ClinicalTrials.gov/show/NCT03975842	Completed	Fondation Ophtalmologique Adolphe de Rothschild	2012-12-31
NCT03693976	Non-interventional Study With Ectoin Containing and/or Decongesting Nasal Spray in Patients With Rhinosinusitis	https://ClinicalTrials.gov/show/NCT03693976	Completed	Bitop AG	2019-04-15
NCT03584737	Point-of-Care Immunoassay for Detection of Bacterial Sinusitis	https://ClinicalTrials.gov/show/NCT03584737	Active, not recruiting	ENTvantage Dx	2020-08-31
NCT03535558	Fluoroquinolone Associated Disability	https://ClinicalTrials.gov/show/NCT03535558	Completed	Janssen Research & Development, LLC	2018-12-31
NCT03480100	Non-interventional Study of Ectoin Nasal Douche (END01) in Patients With Acute Viral Rhinosinusitis	https://ClinicalTrials.gov/show/NCT03480100	Completed	Bitop AG	2018-05-31
NCT03466879	A User Study of SYNUS Pain Relief Made by Tivic Health Systems	https://ClinicalTrials.gov/show/NCT03466879	Completed	Tivic Health Systems	2018-07-21
NCT01255566	Medical Therapy Versus Sinus Surgery for Chronic Rhinosinusitis: A Prospective, Multi-institutional Study	https://ClinicalTrials.gov/show/NCT01255566	Completed	Oregon Health and Science University	2012-07-31
NCT01156701	Prophylactic Efficacy of Relenza Against Influenza A and B	https://ClinicalTrials.gov/show/NCT01156701	Completed	GlaxoSmithKline	2010-05-31
NCT01129765	Home Usability of a Nasal Lavage System in Children	https://ClinicalTrials.gov/show/NCT01129765	Completed	Aardvark Medical Company	2009-08-31
NCT01107379	Optimization and Refinement of Technique in In-Office Sinus Dilation 2	https://ClinicalTrials.gov/show/NCT01107379	Completed	Acclarent	2012-01-31
NCT01032174	Non-Interventional Open Label Prospective Comparative Observational Study Of Evaluation Of Compliance In The Empiric Treatment With Azithromycin SR Versus Amoxiclav 1000 Mg In Adult Patients With Of Acute Bacterial Maxillary Sinusitis	https://ClinicalTrials.gov/show/NCT01032174	Completed	Pfizer	2011-03-31
NCT01002313	Effect of Prednisone onTregs and TH17	https://ClinicalTrials.gov/show/NCT01002313	Completed	University of Chicago	2010-05-31
NCT01001819	DNA Microarray Analysis of Gene Expression in Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT01001819	Completed	Montefiore Medical Center	2008-11-18
NCT01001039	Validation of the Facial and Cephalic Pain Inventory	https://ClinicalTrials.gov/show/NCT01001039	Completed	University of Washington	2011-07-31
NCT00970190	Olfactory Dysfunction of Rhinosinusitis - Cyclic Adenosine Monophosphate (cAMP)/Calcium Signaling Study	https://ClinicalTrials.gov/show/NCT00970190	Completed	University of Washington	2014-04-30
NCT00962689	Clinical Study to Improve Diagnosis and Treatment of Sinusitis	https://ClinicalTrials.gov/show/NCT00962689	Completed	Ohio State University	2013-11-30
NCT00930488	Treatment of Patients With Acute Sinusitis	https://ClinicalTrials.gov/show/NCT00930488	Completed	Bayer	2008-12-31
NCT00847041	Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis.	https://ClinicalTrials.gov/show/NCT00847041	Completed	University of California, San Francisco	NA
NCT00843869	Reversal of Tobacco-Related Sinusitis	https://ClinicalTrials.gov/show/NCT00843869	Completed	University of Alabama at Birmingham	2015-02-28
NCT04418622	Evolution of the Endonasal Microbiota in Patients With Chronic Rhinosinusitis	https://ClinicalTrials.gov/show/NCT04418622	Recruiting	University Hospital, Brest	2021-06-02
NCT00543998	Near Infrared Transillumination of the Paranasal Sinuses	https://ClinicalTrials.gov/show/NCT00543998	Completed	University of California, Irvine	2005-06-30
NCT00517946	A Study To Investigate If MRI Scanning Is Effective At Seeing What Hayfever Drugs Do In Nasal Passage.	https://ClinicalTrials.gov/show/NCT00517946	Completed	GlaxoSmithKline	2007-04-30
NCT00355160	Non-Rhinologic Etiologies of Headaches and Facial Pain in Tertiary Care Setting	https://ClinicalTrials.gov/show/NCT00355160	Completed	Penn State University	2009-04-30
NCT00292851	Blown Nasal Secretion Measurements in Rhinosinusitis: Repeatability and Validity Compared to Nasal Lavage	https://ClinicalTrials.gov/show/NCT00292851	Completed	St. Joseph’s Healthcare Hamilton	NA
NCT00799097	Determinants of Surgical Outcomes in Chronic Sinusitis	https://ClinicalTrials.gov/show/NCT00799097	Completed	Oregon Health and Science University	2009-06-30
NCT00266474	Prevalence of Chronic Rhinosinusitis in Cystic Fibrosis	https://ClinicalTrials.gov/show/NCT00266474	Completed	University of Jena	NA
NCT00797004	Olfactory Dysfunction of Rhinosinusitis	https://ClinicalTrials.gov/show/NCT00797004	Completed	University of Washington	2010-09-30

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03379701	Applications of Nanotechnology and Chemical Sensors for the Detection and Identification of Chronic Sinusitis Subtypes by Respiratory Samples	https://ClinicalTrials.gov/show/NCT03379701	Completed	Hillel Yaffe Medical Center	2016-09-27